A multiple-reader multiple-case receiver operating characteristic (ROC) study was performed. Twenty clinicians, including 7 emergency room (ER) physicians 7 radiology residents and 6 specialists, were recruited as readers of 60 sets of brain CT, including 30 cases that show AIH smaller than 1cm, and 30 controls. Significantly improved performance is observed in ER physicians, average area under the ROC curve (A) increased from 0.83 to 0.95 when they make the diagnosis without and with the support of CAD. And for radiology residents, and specialists, A increased from 0.95 to 0.98, and from 0.97 to 0.98, respectively.
We are in the process of implementing this CAD method for daily clinical operation to aid physicians to improve their AIH diagnostic performance.